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In a study in adult subjects with moderate hepatic impairment (Child-Pugh class B), the plasma concentrations of free paliperidone were similar to those of healthy subjects, although total paliperidone exposure decreased because of a decrease in protein binding.

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In responsive patients, continue as long as clinically necessary and tolerated, but at lowest possible effective dosage; periodically reassess need for continued therapy.

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Hyperglycemia and Diabetes Mellitus: Hyperglycemia and diabetes mellitus, in some cases extreme and associated with ketoacidosis, hyperosmolar coma or death, have been reported in patients treated with all atypical antipsychotics (APS).

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The mechanism of action of paliperidone, as with other drugs having efficacy in schizophrenia, is unknown, but it has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D 2) and serotonin Type 2 (5HT 2A) receptor antagonism.

Some patients may benefit from higher or lower monthly maintenance doses (monthly maintenance dosage range: 39 to 234 mg).

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Food and Drug Administration (FDA) approved the supplemental New Drug Applications (sNDAs) for the once-monthly atypical long-acting antipsychotic INVEGAA SUSTENNAA (paliperidone palmitate) to treat schizoaffective disorder as either monotherapy or adjunctive therapy.

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Suvorexant: CNS Depressants may enhance the CNS depressant effect of Suvorexant.

In this class of drugs, only aripiprazole (Ability) has a Food and Drug Administration indication for this type of depression--as adjunctive therapy in treatment-resistant depression--though manufacturers of some of the others are pursuing approvals for depression.

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The diagnosis of schizophrenia is made both by ruling out other medical disorders that can cause the behavioral symptoms (exclusion), and by observation of the presence of characteristic symptoms of the disorder.

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Invega (paliperidone) is an antipsychotic medication prescribed to treat schizophrenia and schizoaffective disorders in adults and in adolescents between the ages of 12 and 17.

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