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If therapy needs to be discontinued, especially in patients who have been receiving high doses for long periods, the dose should be decreased slowly to minimize the risk of withdrawal and rebound hypertension, tachycardia and hypertonia.

Benzodiazepines require special precaution if used in the alcohol- or drug-dependent individuals and individuals with comorbid psychiatric disorders.

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Dry mouth, somnolence, asthenia and dizziness are the most common side effects.

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Males and females use benzodiazepines for nonmedical purposes equally.

Xanax), while they both have recreational value for the most part, they effect the brain in a very different way and the "high" is very different from one another.

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Each dose of tizanidine only lasts between three and six hours, with a peak in effectiveness happening about one or two hours after taking it.

The review's authors note that the more than 100 different cannabinoids in cannabis have the capacity for analgesia through neuromodulation in ascending and descending pain pathways, neuroprotection, and anti-inflammatory mechanisms.

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