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Pegylated liposomal doxorubicin plus docetaxel significantly improves time to progression without additive cardiotoxicity compared with docetaxel monotherapy in patients with advanced breast cancer previously treated with neoadjuvant-adjuvant anthracycline therapy: results from a randomized phase III study.

The 5 year predicted absolute breast cancer risk accounts for multiple risk factors in an individual and should provide the best estimate of individual benefit (see INDICATIONS AND USAGE).

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This side effect can sometimes be a helpful (if unintended) consequence of chemotherapy with regard to breast cancer treatment.

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Once the patient wakes from anesthesia and is awake and alert, if no signs of problems are present and the patient is able to urinate and pass gas, they can continue their recovery in their own home.

In men, drinking every day raised the risk for cirrhosis more than less frequent drinking.

The long-term effects of Tamoxifen therapy for girls have not been established.

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Certain health problems and drugs that boost osteoporosis risk are specific to men, including some prostate cancer drugs, the researchers pointed out.

Life threatening interaction between tamoxifen and warfarin.

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This complication occurs in fewer than 1 percent of patients given tamoxifen, but deaths due to thromboembolism have been reported.

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Ischemic cardiovascular disease (4%) has also been reported.

If excreted, there are no data regarding the effects of Tamoxifen in breast milk on the breastfed infant or breastfed animals.

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Survival after the diagnosis of breast cancer was similar for combined HT users and nonusers.

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Effects of tamoxifen on autosomal genes regulating ovary maintenance in adult mice.

There was no difference between treatment groups in the total number of these fractures or in the number for any of the specific types of fracture.

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The test was not evaluated in newborns, children, people with AIDS or those whose immune systems were compromised by something else, the FDA said.

We found that tamoxifen treatment had no significant influence on primary tumor weight (Fig.

Tomaszewski D. Biosimilar naming conventions: pharmacist perceptions and impact on confidence in dispensing biologics.

Because of the connection between estrogen levels and breast cancer cell growth, some doctors recommend delaying pregnancy until 2 years after treatment in order to reduce the risk of cancer recurrence and improve odds for survival.

More study is needed to track the IVD for reversibility, Hofmeister said.

Effect of chlorophyll and aqueous extracts of Bacopa monniera and Valeriana wallichii on ischaemia and reperfusion-induced cerebral injury in mice.

Ribeiro G, Swindell R "The Christie Hospital adjuvant tamoxifen trial.

Extending anticoagulation beyond 3 to 6 months has been shown to reduce the risk of recurrence in that highrisk population, according to study authors, who point out that most previous studies did not include followup of patients after treatment ended, so it was uncertain whether the benefit was maintained.

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The other two drugs, letrozole (Femara) and anastrozole (Arimidex), have been approved as either first-line treatment without prior use of tamoxifen or for use following tamoxifen treatment.

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Therefore, it is interesting that of the five tamoxifen metabolites examined, only the serum concentrations of 4OHNDtam was positively associated with the serum levels of FSH in this situation of steady-state tamoxifen kinetics.

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This means that each year, about one of every four recurrences and one of every six deaths can be delayed or averted with tamoxifen treatment.

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Patients with a family or arthritis support the theory that genetic factors may be related to the cause.

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Altering the effect of estrogen in the female body can cause a level of discomfort, so antiestrogens are most bearable when used after the point of menopause.

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Review of hepatotoxicity of tamoxifen mentions that nonalcoholic fatty liver disease is the most common form of liver injury due to tamoxifen which has also been reported to cause peliosis hepatis, acute hepatitis, submassive hepatic necrosis and liver cancer).

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The influence of acculturation and breast cancer-specific distress on perceived barriers to genetic testing for breast cancer among women of African descent.

Women taking Tamoxifen as treatment for metastatic breast cancer should review this monitoring plan with their care provider and select the appropriate modalities and schedule of evaluation.

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For women with oestrogen receptor (ER)-positive early breast cancer, treatment with tamoxifen for 5 years substantially reduces the breast cancer mortality rate throughout the first 15 years after diagnosis.

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Study results revealed that 10 years of tamoxifen reduced the risk of breast cancer recurrence (617 recurrences for 10 years of tamoxifen vs.

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However, direct neonatal exposure of Tamoxifen to mice and rats (not via breast milk) produced 1) reproductive tract lesions in female rodents (similar to those seen in humans after intrauterine exposure to diethylstilbestrol) and 2) functional defects of the reproductive tract in male rodents such as testicular atrophy and arrest of spermatogenesis.

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Women with indolent disease (a disease-free interval lasting more than two years after initial surgery; soft-tissue, bone, or nodular lung metastases; and estrogen or progesterone receptors) have the best response to tamoxifen ( Figure 2 Approach to the Treatment of Women with Metastatic Breast Cancer.

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Pre-evaluations and postevaluations of the decision aid in 20 women showed that use of the aid resulted in a significant decrease in decisional conflict, improvement in knowledge, and a decrease in uncertainty about tamoxifen use, RRM and RRSO.

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Patients who received previous tamoxifen therapy were included.

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